Kintai trial operation of pilot extraction equipment
Kintai pilot workshop is equipped with two 500L pilot extraction tank concentration production line;
The pilot extraction equipment can verify and correct various process parameters, so as to prepare for industrial production optimization process in Kintai factory.
Differences between pilot production and pilot development processes
The difference between small scale process development and pilot production is only the amount of materials and the size of the equipment used. They need to complete different tasks in different periods. The development of pilot scale process is mainly engaged in exploration and development. After the chemical pilot scale process solved the reaction, separation process and the analysis and identification of the materials involved in the determined topic, qualified samples were taken out, and the economic and technical indicators such as yield met the expected requirements, it can be concluded and transferred to the pilot scale stage. The problem to be solved during the pilot scale test is how to use industrial means and equipment to complete the whole process of the pilot scale test and basically reach the economic and technical indicators of the pilot scale test. Of course, the scale has also expanded.
Why pilot production
1. Different scales
2. Different sources of raw materials
3. Different mixing methods
4. Different heat transfer modes
5. Different materials of reactors
Purpose of pilot production enlargement
Pilot production is a necessary transition link from small scale experiment to industrial production; In terms of production equipment, the transition from small test to production operation is basically completed to ensure that the products with predetermined quality standards can always be produced according to the operating procedures; It refers to the process of using small production equipment for production. The design requirements, selection and working principle of the equipment are basically consistent with those of large production; After the pilot scale test is mature, conduct pilot scale test to study feasible industrialization process and equipment selection, so as to provide basis for industrial design. Therefore, the purpose of pilot scale up is to verify, review and improve whether the synthetic process route determined by the laboratory process is mature and reasonable, and whether the main economic and technical indicators are close to the production requirements; Study the structure, material, installation and workshop layout of the selected industrial production equipment to provide data and the best material quantity and material consumption for formal production.
Importance of pilot production enlargement
Pilot production refers to small scale production simulation test, which is based on small scale experiment to study the feasible scheme of industrialization. It further studies the change law of chemical reaction conditions in each step of a certain scale device, and solves problems that cannot be solved or found in the laboratory, providing design basis for industrial production. Although the nature of chemical reaction will not change due to different experimental production, the optimal reaction process conditions for each step of chemical reaction may change with the external conditions such as experimental scale and equipment. Generally speaking, pilot scale up is an important transition stage from rapid, high-level to industrial production, and its level represents the level of industrialization.
Scale up of pilot production is the way from drug R&D to production, and also an effective measure to reduce the risk of industrialization.
