Part1. What is angelica acutiloba root extract?
Angelica sinensis extract is a product extracted from the dried root of Angelica sinensis D., an umbrella plant. Commercial extracts are usually standardized to contain 0.1% ferulic acid and 0.8% ligustilide.
Part2. Source of medicinal materials
Angelica is a commonly used traditional Chinese medicine. The medicine can not only improve blood circulation, but also replenish blood deficiency. Angelica is also known as Qingui (Gansu, Sichuan, Yunnan), Yungui (Yunnan), West Angelica, and Min Angelica (Gansu).
Part3. Function Indications
Regulating menstruation and relieving pain, enriching blood and nourishing blood, promoting blood circulation and relieving pain, moistening bowel and laxative. Cure mainly irregular menstruation, amenorrhea, abdominal pain, lump in the abdomen, metrorrhagia; blood deficiency headache, dizziness, impotence; dryness of the intestines, difficulty in defecation, heavy dysentery; carbuncle sores, injuries from falls; Enhance gastrointestinal absorption; wine angelica promotes blood circulation and stimulates menstrual flow. For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling.
Part4. Clinical efficacy
Angelica sweet, pungent, warm. Return liver, heart, spleen channel. Enriches and activates blood circulation, regulates menstruation and relieves pain, laxes bowels. For blood deficiency and yellow complexion, dizziness and palpitations, irregular menstruation, amenorrhea dysmenorrhea, abdominal pain due to deficiency and cold, constipation due to dryness of the intestine, rheumatic arthralgia, injury from falls, carbuncle sores.
Since ancient times, angelica has been used as the main medicine in gynecology. With the deepening of the research on the chemical components and pharmacological effects of angelica, the scope of medicinal use has been continuously expanded. Vasculitis, cerebral arteriosclerosis, high blood pressure, migraine, liver cancer, acute nephritis, habitual constipation, gastric ulcer dysmenorrhea, superficial phlebitis, frozen shoulder and other diseases.
Angelica extract has the function of two-way regulating menstruation, can alleviate menopausal syndrome, and relieve dysmenorrhea, amenorrhea, uterine cramps, etc. by increasing the blood circulation of the reproductive system;
Angelica extract can increase the number of red blood cells and platelets, which can be used for some diseases caused by anemia;
Anti-infection, pain relief, can be used for pain caused by blood stasis, can strengthen metabolism, promote intestinal peristalsis, help digestion, and can be used for constipation caused by intestinal dryness;
It can increase the liver's absorption of oxygen, purify the blood, nourish the brain, heart, spleen and protect the liver and detoxify. It can also promote circulation, lower blood pressure and fat, and relieve rheumatic pain.
Part5. Pharmacological effects
1. The effect on the cardiovascular system
Angelica water extract has antithrombotic effect, can promote the activity of plasma fibrinolytic enzymes, and improve blood rheology.
1) The effect on the heart
Angelica decoction or volatile oil has inhibitory effect on the isolated toad heart, and it is strengthened with the increase of dose.
2) Antiarrhythmic
Angelica water extract (3g/kg, 6g/kg) and ethanol extract (4g/kg) have obvious antiarrhythmic effects on various animal arrhythmias induced by adrenaline, cardiac glycosides and barium chloride.
3) Reduce vascular resistance and lower arterial blood pressure
For anesthetized animals, Angelica injection (2g/kg) can expand peripheral blood vessels, reduce vascular resistance, increase femoral artery blood flow, cerebral blood flow and coronary blood flow.
2. Effects on blood system
Angelica water extract can improve cerebral circulation, peripheral circulation and coronary circulation, and can reduce myocardial oxygen consumption. Angelica can increase the number of peripheral blood red blood cells, white blood cells and hemoglobin, especially when the peripheral blood cells are reduced or the bone marrow is suppressed.
3. Effect on smooth muscle
Angelica extract has obvious relaxation effect on vascular smooth muscle, intestinal smooth muscle, uterine smooth muscle and tracheal smooth muscle, and has the effect of relieving spasm and relieving asthma.
4. Gallbladder-protecting and liver-protecting effect
Angelica extract can increase bile secretion rate. Promote digestive function, improve liver cell membrane damage, liver cell mitochondrial damage and lysosome membrane damage.
5. Effects on immune function
The water extract of Angelica sinensis can enhance the specific and non-specific immune function. Using the clearance rate of plasma protein colloid particles in mouse blood as the function index of monocyte phagocytic system, it was observed that Angelica sinensis has a certain effect of promoting phagocytosis.
6. Analgesic effect
As a traditional Chinese medicine, Angelica has good analgesic effect. Japanese scholars have proved through pharmacological experiments that the analgesic effect of Japanese angelica water extract is 1.7 times that of acetylsalicylic acid, and its analgesic active ingredients are polyacetylene compounds falcarindiol and falcarinolone. In addition, Japanese scholars also proved that the analgesic effects of Chinese Angelica sinensis and Dong Angelica sinensis are similar. Angelica extract can inhibit platelet AA metabolism and platelet 5-HT release, and has mild analgesic effect. Anti-tumor effect Angelica sinensis extract has obvious inhibitory effect on tyrosinase, and can inhibit the monophenolase activity and diphenolase activity of tyrosinase. The inhibition of p-diphenolase showed a reversible competitive inhibition type. Studies have confirmed that different extracts of Angelica sinensis can effectively inhibit tumor growth and show certain anti-tumor activity. Besides polysaccharides and volatile oils, Angelica has other components, many of which have certain antitumor activity. The good pharmacological activity of different extracts of Angelica sinensis in anti-tumor is the uniqueness of traditional Chinese medicine in anti-tumor. Compared with chemical drugs, Angelica sinensis anti-tumor has the characteristics of high efficiency and low toxicity, which is unique in tumor treatment compared with chemotherapy. It is superior, not only can produce better curative effect, but also can protect the normal tissue cells of the body.
Part6. Application
Angelica is a traditional Chinese medicine in my country, which is widely used. There are quite a lot of prescriptions and compound preparations recorded in Chinese Pharmacopoeia and ministerial standards, which are mainly used to nourish blood and regulate menstruation. Recent unilateral or extract preparations include: oral preparations made of volatile oil of Angelica sinensis—Danggui Funing Dropping Pills, which are made of Angelica sinensis extract powder (0.1%~1.1% ligustilide, 1% ferulic acid) Capsules are widely used as food supplements for the treatment or adjuvant treatment of various gynecological diseases. Merck's Angelica extract "Youyoulu" is sold well all over the world.
